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10 Best Glutathione Supplements of 2022 (Tested & Ranked)

Do you want to look healthier, feel younger and boost your energy levels? Check out the top 10 best Glutathione Supplements reviewed in the article. 
Steve Theunissen, PT

Written by Steve Theunissen, PT

Last Updated onMay 30th, 2022

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Glutathione is a combination of three amino acids — glycine, cysteine, and glutamic acid, produced in the liver and nerve cells of the central nervous system. 

It is an antioxidant that helps fight free radical damage to the body’s cells that can otherwise result in inflammation and health problems, including Alzheimer’s disease, high blood pressure, and diabetes. 

Often referred to as the ‘mother of all antioxidants,’ Glutathione is one of the most exciting overall health boosters to appear in a long time. In this article, we dig deep into the health supplement market to bring you the top 10 best glutathione supplements of 2022

Top 10 Glutathione Supplements Tested/Ranked

Note — The content on FitnessVolt is for informative purposes only and should not be taken as medical advice to diagnose, prevent, and/or treat health problems. If you’re suffering from a health issue, are pregnant, or are under 18-years-old, you should consult your physician before starting any new supplement, nutrition, or fitness routine.

How Much Do Pre-Workouts for Beginners Cost?

There is a wide range of glutathione supplements available on the market. Here’s a breakdown of the overall and per serving costs of our top 10 —

CategoryProductNamePricePer ServingWhy We Love It
Best OverallNatures Craft Best Glutathione SupplementNature’s Craft Glutathione$37.99$0.63Contains Liposomal Glutathione and milk thistle for enhanced effect.
Best ValueWe Like Vitamins Glutathione ReducedWe Like Vitamins Glutathione Reduced$24.99$0.12It delivers an excellent per-dose cost. This is a pure single-ingredient product.
Best for PurityToniiq Glutathione SupplementToniiq Glutathione$31.97$0.27It’s got 98% purity and is third-party tested.
Best Bulk SupplyJarrow Formulas Glutathione SupplementJarrow Formulas Glutathione Supplement$45.42$0.38This is another pure, single-ingredient product. We love the bulk supply price also.
Best with Alpha Lipoic AcidNow Foods GlutathioneNOW Foods Glutathione$22.00$0.37Contains alpha-lipoic acid and milk thistle extract.
Best Powder FormBulk Supplements Glutathione ReducedBulk Supplements Glutathione Reduced$15.96$0.12We love that the powder form can be mixed with your pre-workout.
Best Vegetarian-FriendlyFresh Nutrition Glutathione ReducedFresh Nutrition Glutathione Reduced$19.99$0.22It’s third-party tested and a vegetarian product.
Best Third Party TestedA Squared Nutrition GlutathioneA Squared Nutrition Glutathione$39.99$0.20A third-party tested product that contains 200 servings.
Best AntioxidantPure Encapsulations GlutathionePure Encapsulations Glutathione$47.30$0.39It’s a pure, simple, single-ingredient product.
Best Reduced FormSolgar Reduced L Glutathione SupplementSolgar Reduced L-Glutathione$28.78$0.48This is a reduced form of glutathione. We love the recyclable amber glass bottle.

Products Reviews

Here are the top 10 best glutathione supplements money can buy — 

Best Glutathione Supplement Overall

Our best-rated glutathione supplement provides you with exactly what you need in an antioxidant and is a general health enhancer. It contains liposomal glutathione, which is the most bioavailable form and is enhanced with milk thistle extract, making it even more potent. 

Nature’s Craft Glutathione

Natures Craft Best Glutathione Supplement
Natures Craft Glutathione

Nature’s Craft Glutathione is a liposomal glutathione product, making it one of the best sources of this compound for absorption and bioavailability. Nature’s Craft sources its ingredients from non-GMO sources. It also includes milk thistle extract, which can help improve liver functioning.

Each capsule of Nature’s Craft Glutathione gives you 500 mg of glutathione and 100 mg of milk thistle extract. It is manufactured in GMP-certified facilities to ensure the highest quality and purity levels. 

There are no additives, flavorings, or preservatives in Nature’s Craft Glutathione.

Who Should Take Nature’s Craft Glutathione?

  • People who want a pure, high-quality liposomal glutathione product.

Who Should Not Take Nature’s Craft Glutathione?

  • Those who want a flavor-enhanced source of glutathione.


Nature’s Craft Glutathione Coupon

Nature’s Craft Glutathione contains 500mg of l-glutathione plus 50mg alpha-lipoic acid and milk thistle. It is one of the most 'complete' glutathione supplements on the market and hence takes the 'Best Overall' crown. 

Best Value Glutathione Supplement

The best value glutathione supplement on our list breaks down to just 0.12 cents per serving. That’s a whole eight cents cheaper than the next closest competitor.

We Like Vitamins Glutathione Reduced

We Like Vitamins Glutathione Reduced
We Like Vitamins Glutathione Reduced

With 200 capsules per bottle, We Like Vitamins Glutathione Reduced is a value for money product, working out to just 12 cents per capsule. You get 500 mg per serving to provide you with a generous daily dosage of Glutathione.

The only other ingredients in We Like Vitamins Glutathione are those that make up the gelatin capsule: gelatin, magnesium stearate, microcrystalline cellulose (plant fiber), and silica. Gelatin is non-vegetarian sourced, so vegetarians will want to avoid this product. 

This product is manufactured in the United States in a Good Manufacturing Practises certified facility. 

We Like Vitamins partners with Vitamin Angels to provide access to health supplements to women and children in need. 

Who Should Take We Like Vitamins Glutathione Reduced?

  • Individuals who want the best price on their Glutathione supplement.

Who Should Not Take We Like Vitamins Glutathione Reduced?

  • Vegetarians.


We Like Vitamins Glutathione Reduced Coupon

We Like Vitamins Glutathione Reduced is one of the few glutathione supplements on the market that comes with a 30-day money-back guarantee. It tells us that the manufacturer stands behind this product.

Best Glutathione Supplement for Purity

The purer a supplement is the more of it will be available as an antioxidant and health enhancer. Our top product in this category is an incredible 98% pure.

Toniiq Glutathione

Toniiq Glutathione Supplement
Toniiq Glutathione

Toniiq Glutathione provides a 98 percent purity product. Toniiq products are also third-party tested for the following —

  • Amount per serving
  • Percentage of active ingredients
  • Aerobic plate count
  • Microbial specifications
  • Heavy metal specifications

Each container of Toniiq Glutathione contains 120 capsules. There is 250 mg in each capsule with a serving size being two capsules. 

Who Should Take Toniiq Glutathione?

  • People who want the best quality product.

Who Should Not Take Toniiq Glutathione?

  • People who want extra ingredients in their glutathione supplement.


Toniiq Glutathione Coupon

Each serving of Toniiq Glutathione contains 1000mg glutathione at an impressive 98% purity level. High purity translates to better supplement bioavailability. 

Best Bulk Supply Glutathione Supplement

Buying in bulk can save you a lot of money in the long term. With 120 capsules packed into each container, Jarrow Formulas Glutathione gets you the best bang for your buck.

Jarrow Formulas Glutathione Supplement

Jarrow Formulas Glutathione Supplement
Jarrow Formulas Glutathione Supplement

Jarrow Formulas Glutathione Supplement contains 120 capsules per bottle and is dosed at 500 mg per serving. This is a pure glutathione product that contains nothing but the main ingredient. Being a vegetarian capsule, it contains no gelatin, cellulose, magnesium stearate (vegetable source), and silicon dioxide.

All Jarrow Formulas products are manufactured in Current Good Manufacturing Practices (cGMP) certified facilities.

Who Should Take Jarrow Formulas Glutathione Supplement?

  • Those who want a pure, vegetarian-friendly glutathione supplement.

Who Should Not Take Jarrow Formulas Glutathione Supplement?

  • People who want extra ingredients in their glutathione supplement.


Jarrow Formulas Glutathione Supplement Coupon

Jarrow Formulas Glutathione Supplement is a pure, single-ingredient product that is a hit amongst users. It has received a 4.5-star rating from over 3,000 reviews on Amazon. 

Best Glutathione Supplement with Alpha Lipoic Acid

Combining Alpha Lipoic Acid with glutathione improves brain function, helps to relieve nerve pain, and boosts the antibiotic power of the supplement. 

NOW Foods Glutathione

Now Foods Glutathione
Now Foods Glutathione

NOW Foods Glutathione is a reduced active form of the supplement to improve its free-radical fighting ability. Every 500 mg capsule of NOW Foods is supplemented with two key extra ingredients —

  • Alpha-lipoic acid
  • Milk thistle extract

These ingredients will boost the health-boosting benefits of glutathione by improving brain functioning, relieving nerve pain, and protecting against inflammation. 

NOW Foods Glutathione is soy-free, non-GMO, vegan, nut-free, gluten-free, and dairy-free. It is manufactured in an A-rated GMP facility in the USA. 

Who Should Take NOW Foods Glutathione?

  • People who want a glutathione product that is fortified with alpha-lipoic acid and milk thistle extract.

Who Should Not Take NOW Foods Glutathione?

  • People who want a single ingredient glutathione product.


NOW Foods Glutathione Coupon

NOW Foods Glutathione combines glutathione with alpha-lipoic acid and milk thistle extract, which boosts the antibiotic power of the supplement, enhances cognitive abilities, and helps relieve nerve pain. 

Best Powder Form Glutathione Supplement

When you buy your glutathione supplement in powder form, you can add it to your pre-workout or any other beverage. The powder form also works out to be more cost-effective.

Bulk Supplements Glutathione Reduced

Bulk Supplements Glutathione Reduced
Bulk Supplements Glutathione Reduced

Bulk Supplements Glutathione Reduced provides you with a no-frills bag of pure and unadulterated glutathione at a bulk food price. This is the only powdered glutathione supplement to make our top 10 list. That allows you to mix your supplement in water or a beverage or use it in your pre or post-workout shake.

Bulk Supplements Glutathione Reduced provides you with glutathione in its purest form. It is gluten-free, dairy-free, soy and yeast-free, and has no added sugar. 

However, assessing your exact dosage when taking glutathione in powder form can be difficult. If you want a faster and simpler way to get the same dosage every day, you should take a capsule form version of the supplement. 

Who Should Take Bulk Supplements Glutathione Reduced?

  • People who want to take their glutathione product in powder form.

Who Should Not Bulk Supplements Glutathione Reduced?

  • Individuals who prefer a capsule-form supplement.


Bulk Supplements Glutathione Reduced Coupon

Bulk Supplements Glutathione Reduced is the only powered glutathione supplement on the list and is one of the most budget-friendly glutathione supps on the market. 

Best Vegetarian-Friendly Glutathione Supplement

Some capsuled form supps may contain gelatin or other animal-based ingredients in the capsule. Our best vegetarian-friendly supplement is 100% vegetarian friendly, including the capsule. 

Fresh Nutrition Glutathione Reduced

Fresh Nutrition Glutathione Reduced
Fresh Nutrition Glutathione Reduced

Fresh Nutrition Glutathione Reduced provides 500 mg of liposomal glutathione per serving. This product is a reduced form of glutathione, making it a more potent antioxidant. There is 166.66 mg of glutathione per capsule, with a serving being three capsules.

Each 90 capsule container of Fresh Nutrition Glutathione Reduced is third-party tested for potency, quality, and purity. As a result of the vegan capsule, this is a vegetarian-friendly, non-GMO, soy-free, and gluten-free product. It is also free of sugar, preservatives, or flavorings. 

Who Should Take Fresh Nutrition Glutathione Reduced?

  • Lifters who want a pure, third-party tested form of glutathione.
  • People who are looking for a vegetarian glutathione supplement.

Who Should Not Take Fresh Nutrition Glutathione Reduced?

  • Individuals who want extra ingredients in their glutathione supplement.


Fresh Nutrition Glutathione Reduced Coupon

Fresh Nutrition Glutathione Reduced is a DNA verified and third-party tested vegetarian glutathione supplement that is non-Gmo, gluten-free, soy-free, and has no artificial flavors, colors, or preservatives.

Best Third-Party Tested Glutathione Supplement

Third-party testing reinforces the quality of the product and the ingredients used. It ensures you are getting what you expect with no nasty surprises.

A Squared Nutrition Glutathione

A Squared Nutrition Glutathione
A Squared Nutrition Glutathione

A Squared Nutrition Glutathione provides a reduced version of the supplement to make it even more powerful as an antioxidant. There are 200 capsules in each container, making for an affordable product. The serving size is two capsules per day, so you get a full hundred-day supply with each purchase.

The vegetable cellulose capsule makes for a vegetarian-friendly product. It is also gluten, dairy, and soy-free. It is manufactured in the USA in a GMP-certified facility. This product also undergoes third-party testing before being released onto the market.

Who Should Take A Squared Nutrition Glutathione?

  • People who want to buy third-party-tested glutathione supplements in bulk.

Who Should Not Take A Squared Nutrition Glutathione?

  • Individuals who want extra ingredients in their glutathione supplement.


A Squared Nutrition Glutathione Coupon

A Squared Nutrition Glutathione is a third-party tested supplement that contains 500mg glutathione per serving, and 200 vegetable capsules per bottle.

Best Glutathione Supplement for Antioxidants

Glutathione is a powerful antioxidant. Our leader in this category does a great job of helping your body ward off toxins.

Pure Encapsulations Glutathione

Pure Encapsulations Glutathione
Pure Encapsulations Glutathione

Pure Encapsulations has a reputation for providing pure, filler-free supplements at a good price. Their glutathione supplement is a great example of this, with nothing but reduced glutathione in the capsule. 

You get 120 capsules per container, with each serving providing you with 100 mg of glutathione. This product is free of gluten, hydrogenated fat, magnesium stearate, artificial coatings, or sweeteners. That makes for a truly pure, natural form of this powerful antioxidant supplement. 

At just 100 mg of glutathione per serving, Pure Encapsulations is the lowest dosage of all the glutathione supplements on this list. While there is no stated daily recommendation, that may be too low for some people. 

Who Should Take Pure Encapsulations Glutathione?

  • People who want an extremely pure form of glutathione.

Who Should Not Take Pure Encapsulations Glutathione?

  • Folks who want a high dosage of glutathione.


Pure Encapsulations Glutathione Coupon

Pure Encapsulations Liposomal Glutathione supports liver health and detoxification. It is one of the purest, filler-free glutathione supplements you can buy.

Best Reduced Form Glutathione Supplement

Having too much of a supplement can be worse than not having enough. This reduced form of glutathione provides an effective dose without going overboard.

Solgar Reduced L-Glutathione

Solgar Reduced L Glutathione Supplement
Solgar Reduced L Glutathione

Solgar Reduced L-Glutathione is a reduced form of glutathione to boost its antioxidant effect. There are 60 vegetable capsules in a tub, with each serving providing 250 mg of glutathione. There are no other ingredients in this product, making it completely GMO dairy and gluten-free. There are no artificial sweeteners, preservatives, or coloring in this supplement. 

Solgar Reduced L-Glutathione comes in a recyclable amber glass bottle. This protects the supplement against heat, light, and moisture. 

At 250 mg per serving, Solgar Reduced L-Glutathione is dosed at half of the standard dosage. Even though there is no research recommended dosage, you could prefer a higher dose option. 

Who Should Take Solgar Reduced L-Glutathione?

  • Folks who want a pure, unadulterated form of glutathione.

Who Should Not Take Solgar Reduced L-Glutathione?

  • Those who want a higher-dosed product.


Solgar Reduced L-Glutathione Coupon

Solgar Reduced L-Glutathione is an underdosed reduced form glutathione supplement that is great for beginners. 

What is Glutathione?

Glutathione is a combination of three amino acids —

  • Glycine
  • Cysteine
  • Glutamic Acid

Known as GHS, glutathione is naturally produced in the liver and the nerve cells of the central nervous system. It is an antioxidant that helps to fight free radical damage to the body’s cells. An excess of free radicals over antioxidants will result in inflammation and several health problems, including Alzheimer’s disease, high blood pressure, and diabetes. 

Glutathione has also been shown to play a role in DNA creation and repair, protein production, and the activation of enzymes. It is also involved in the breakdown of nutrients for absorption and digestion. 

Research into potential side effects of glutathione is incomplete. There is evidence that supplementing with glutathione may cause bloating and cramping in some people. Some people have also experienced allergic reactions to the supplement, like a body rash.

Researchers believe that the key active ingredient in glutathione is cysteine. Furthermore, glutathione is abundant in many fruits and vegetables and freshly prepared meats. 

What to Look For in a Glutathione Supplement

Even though they may look alike, not all glutathione supplements are equal. Here are three key things to look out for to make sure that you are getting a high-quality supplement —


If your body is unable to absorb the supplement, it doesn’t matter how good the ingredients in a supplement are. When it comes to the bioavailability or absorbency of glutathione, you should go with liposomal glutathione.

So what is liposomal glutathione? It is glutathione that has been encapsulated using liposomal technology in minute fat bubbles to protect the three amino acids that make up the compound (cysteine, glutamine, and glycerine). It allows them to pass directly through the intestine and into the bloodstream, improving the bioavailability of the compound.

You should also make sure that your glutathione supplement is reduced. It is a process by which the oxygen is reduced, and hydrogen and electrons are increased. The process makes the supplement more effective in its ability to fight free radical damage. 

Ingredient Quality

Check the label to ensure the glutathione in the product comes from a non-GMO source. That means it should not be made from soy lecithin, which contains GMOs. A much better option is non-GMO sunflower lecithin. 

Glutathione contains a high concentration of sulfur, which gives it a sulfuric taste and smell. To mask this, many manufacturers add sugar and other sweeteners to the product. You should check that the product does not contain artificial sweeteners such as aspartame or sucralose. Instead, look for a supplement that uses natural flavors and stevia.


Look for a manufacturer that provides complete transparency about their product. It should tell you where the product is manufactured and what the ingredients and dosages are (no proprietary blends). The manufacturer should also have verified user reviews on their website. Furthermore, companies that use third-party testing should be preferred.

How We Decided Our Picks

In narrowing it down to our top 10 glutathione supplements, we considered a large number of products. In making our selections, we took the following factors into account —


We carefully checked the label on all of the glutathione supplements we reviewed to ensure they provided a large enough dose of the active ingredient to do what it promises. 

However, that doesn’t mean that we only included higher-dose supplements because there are no research guidelines regarding glutathione dosage. Hence, we included higher and milder doses to suit all needs. 


When you buy a glutathione supplement, you deserve to get a pure product. We carefully checked out short-listed products to ensure they were free from fillers, preservatives, and flavorings. 

Third-Party Testing

Companies that use third-party testing to verify the potency and purity of the supplements provide you with a high level of consumer confidence. That’s why we favored manufacturers who employed third-party testing on their glutathione supplements. 

Glutathione Supplement Dosage

There are currently no direct research-based recommendations regarding glutathione supplementation dosage. Studies have generally been specific to the treatment of particular conditions and have used widely disparate dosages.

In the absence of a definitive clinical recommendation, we recommend that you follow the manufacturer’s guidelines as far as dosage goes.

What are the Benefits of a Glutathione Supplement?

Glutathione is one of the most powerful antioxidants on the market. It can negate the destructive activity of free radical molecules that cause damage to the cells of the body. The stress caused by intense exercise is believed to increase free radical activity, making it especially beneficial for people who regularly engage in intense exercise. 

Here are six other benefits of taking a glutathione supplement —

  • Helps with psoriasis.
  • Reduces cell damage caused by fatty liver disease.
  • Improves insulin resistance.
  • Increased mobility for those with peripheral artery disease.
  • Reduces symptoms of Parkinson’s disease.
  • Helps offset the biomarkers of aging.

Many people also claim that glutathione can lighten a person’s skin. There are many glutathione-based skin whitening products on the market. However, there is very little research to support the idea.


Who Should Take a Glutathione Supplement?

Glutathione is a general health and well-being supplement that can benefit everybody. As a powerful antioxidant, it could improve the overall health of whoever takes it. 

What does glutathione do for the body?

Glutathione acts as an antioxidant to fight against the destructive activity of free radical molecules that damage the body’s cells. It also helps with food absorption, protein production, enzyme activation, and energy production.

Does glutathione lighten the skin?

There is some evidence that glutathione may cause skin lightening. In some countries, it is marketed as a skin-lightening product. However, the skin brightening effect of glutathione appears to only work when you apply it topically before exercise.

Will glutathione harm my kidneys?

No, glutathione will not harm your kidneys. The kidneys require a good supply of glutathione to carry out their functions. The kidneys are also subject to a high level of potentially damaging oxidants. Being a powerful antioxidant, glutathione is beneficial for the kidneys. 

Does glutathione cause weight gain?

No, glutathione does not cause weight gain. In fact, it supports weight loss. It helps the liver remove toxins from the body that can cause weight gain. Glutathione also helps the body burn off fat cells. 

When should I take glutathione?

Glutathione should be taken on an empty stomach first thing in the morning. 

The Bottom Line

Glutathione is a fantastic antioxidant supplement that will improve your health, vitality, and digestion. If you are a regular exerciser, it can also help improve your workout recovery as it offsets the free radical damage of exercise-induced training stress. 

We hope this review provides you with the necessary information for making an informed buying decision. 

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Steve Theunissen, PT
Steve Theunissen, PT
Steve Theunissen is a former gym owner and personal trainer and is the author of six hardcopy books and more than a hundred ebooks on the topics of bodybuilding, fitness and fat loss. Steve also writes history books with a focus on the history of warfare. He is married and has two daughters. Steve hold the following certifications from the International Sorts Sciences Association: * Certified Personal Trainer * Fitness Nutrition Certification * Specialist in Group Fitness & Guided Study * Strength & Conditioning Certification * Sports Nutrition Certification * Transformation Specialist & Guided Study

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